The Flann O'Brien Rooms is located in Via Nazionale, which is right in the heart of the city. The major historical sites are all within easy reach, including the Colosseum, the Trevi Fountain, and the Forum. The hotel also offers easy access to museums and other leisure activities. The Flann O'Brien Rooms is located only a short drive from the airport, which along with other attractions can be reached via rental car service, taxi cab, public bus, or metro.

All of the guestrooms at the hotel offer luxurious amenities. The Flann O'Brien Rooms offers a variety of bedroom layouts and all rooms are climate controlled and have a private bathroom. Standard amenities include minibars, safes, phones, LCD televisions, satellite service, and desks.

Shopping and dining options are plentiful near the hotel. Guests will find that there is a restaurant located right onsite. The hotel also offers a lounge bar, as well as banquet rooms and a tour desk.